Download PDF Neanderthal Man: In Search of Lost Genomes By Svante Pääbo
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Ebook About A preeminent geneticist hunts the Neanderthal and Denisovan genomes to answer the biggest question of them all: how did our ancestors become human?Neanderthal Man tells the riveting personal and scientific story of the quest to use ancient DNA to unlock the secrets of human evolution. Beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in the sequencing of the Neanderthal genome in 2010, Neanderthal Man describes the events, intrigues, failures, and triumphs of these scientifically rich years through the lens of the pioneer and inventor of the field of ancient DNA. We learn that Neanderthal genes offer a unique window into the lives of our ancient relatives and may hold the key to unlocking the mysteries of where language came from as well as why humans survived while Neanderthals went extinct. Päo redrew our family tree and permanently changed the way we think about who we are and how we got here. For readers of Richard Dawkins, David Reich, and Hope Jahren, Neanderthal Man is the must-read account of how he did it.Book Neanderthal Man: In Search of Lost Genomes Review :
Neanderthal Man: In Search of Lost Genomes by Svante PaaboSvante Paabo is the Mick Jagger of Recombinant DNA Anthropology. I know this because I saw him on an unrelated TV program and you could see the young female Neanderthal professor simply quiver in his presence.So, it's probably not surprising that a surprisingly large portion of this book involves his personal life. I suspect that he imagined himself fighting the stereotype of cold, impersonal science with his personal reflections. Perhaps, but there was an awful lot of barely covered up infighting, concern about political correctness, and calculations about how not to be upstaged. Actually, in a way, that may be the more important historical angle; Paabo offers an insight into the culture of science as it is actually practiced.On the other hand, there was really some personal information that we didn't need. Paabo lost a lot of empathy for me - and, in fact, reinforced the image of the out of touch science nerd - with his story about how he went from out of the closet homosexual to heterosexual parent by committing adultery with a married colleague, who was so cool with this cuckolding that he moved to Germany, took a job with Paabo, and, apparently, welcomes Paabo into the family.Yuck!Another large, large portion of the book is the inside story of how recombinant DNA research is done. Actually, I found this interesting because I've heard the terminology for years and Paabo was able to explain it. Nonetheless, this stuff went on for a long time. Again, though, as a history of the field, this book will probably be a treasure to future historians of science.The gosh-wow! information was mostly relegated to the final chapters wherein we hear about Neanderthal gene flow into Homo Sapiens, e.g., all non-Africans have around 3% of the Neanderthal genetic information. Paabo was also the person who discovered that Denisovans were a new....species? sub-species? race?...it's not clear. Paabo explains:"The final mappings didn’t change the picture, and I became convinced that the Denisova girl was a member of a population that shared a common origin with Neanderthals, but that had lived separately from the Neanderthals for at least as long as Finns today have been separated from, say, the San in southern Africa. Denisova DNA sequences tended to be a bit closer to those of Eurasians than to Africans, but less so than were the Neanderthal DNA sequences. This was best explained by a common ancestry for the Denisova girl and Neanderthals so that when Neanderthals mixed with modern humans, Eurasian ancestors inherited DNA sequences that were somewhat similar to Denisova DNA sequences just because the Neanderthals were related to the Denisova girl."That was probably the most surprising bit of the book. The Denisovans have been presented in the popular media as a completely new species, but that doesn't seem to be the case.I thought the book was interesting. It should have been a lot more tedious than I found it to be. However, it didn't have the attention grabbing, gosh-wow! interest that I expected. So, rather than 5 stars, I've rolled it back a star based on my subjective expectations. I suspect that for reader not looking for a deep dive into chemistry and lab techniques the rating will be much lower. With the completion of the full human genome sequence in 2003 and the rapid fall in DNA sequencing costs over the subsequent 10 years, we have been awaiting major advancements in many fields such as Healthcare, Agriculture, Drug Discovery and so on. However, the progress has been slow and the deluge of genome sequence data has been a tough problem to handle.But, Svante Paabo in this fascinating book on the 'Neanderthal Man' shows how the new technologies have enabled him to sequence the genomes of our extinct relatives - the Neanderthals and the Denisovans. The data proves how our ancestors moved out of Africa about 50,000 years back and interbred to a small extent (2 to 7% of our genes come from them) with the Neanderthals and Denisovans and maybe drove them to extinction. Many interesting facts come out of these studies such as, (a) that gene flow seems to have been from the Neanderthals to us (and not the other way), (b) the founding population of the Neanderthals also seems to have pretty small like in the case of the humans (c) we split from the Neanderthals about 500,000 years back (d) the Denisovans split about 1 million years back (e) the Denisovans seem to be closer to the Neanderthals than to humans, and much more...The book is not only fun to read, but Paabo's detective mode of story telling will also keep the reader focused. By mixing his personal stories with scientific research, Paabo provides a refreshing frankness to the narrative. We get a direct view of the challenges in scientific research and how the role of institutional support and adequate funding can make research a success. Paabo's journey from Egyptian mummies to Mammoths, to Sloths and finally the Neanderthals and Denisovans is a great inspiration to all students of science. He shows how passion, perseverance, attention to detail, and collaboration can deliver results not only in Science but in all aspects of life.Paabo explains the Science very clearly and the narrative shows us how he has become the world's expert in 'ancient DNA'. But in order to do that he often has to go into intricate details of lab work which some readers might find difficult to follow. Still it will not affect the story and if you are interested to learn how we became what we are, this is a book that you should not miss. 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